Forever Cousins by Laurel Goodluck

Apraxia Laurel

pRb or its cousins

Mechanisms controlling the p53 regulatory network remain the focus of numerous investigations in hopes of identifying more robust cancer therapies. Both Mdm2 and MdmX are found overexpressed in tumors with wild-type p53 and represent a key molecular device modulating p53 function. Thus, examining the interplay between these three proteins becomes highly relevant in the search for new pharmacolo...

Forever Young

Propagation of a species requires periodic cell renewal to avoid clonal senescence. Liu et al. (2010) now describe a new mechanism of cell renewal in budding yeast, in which damaged protein aggregates are transported out of the daughter buds along actin cables to preserve youthfulness.

Revision Forever!

Revision is a method to deal with non-monotonic processes. It has been used in theory of truth an an answer to semantic paradoxes as the liar, but the idea is universal and resurfaces in many areas of logic and applications of logic. In this survey, we describe the general idea in the framework of pointer semantics and point out that beyond the formal semantics given by Gupta and Belnap, the pr...

Bricolage forever!

According to constructivism, learning takes place by constructing cognitive structures. An experiment was carried out to uncover the mental models of experienced, but not professional, users of a word processor. The study shows that the mental models are superficial, and that bricolage (trial-and-error) is extensively used even though it is not viable for solving nontrivial problems. The conclu...